SECRETION OF HUMAN GROWTH HORMONE DURING INSULIN COMA AND ELECTROSHOCK THERAPIES
Kiyohisa Takahashi M.D.1,
Saburo Takahashi M.D.1,
Yutaka Honda M.D.1,
Kazuo Shizume M.D.2,
Minoru Irie M.D.2,
Maki Sakuma M.D.2
Toshio Tsushima M.D.2
Article first published online: 17 MAR 2008
DOI: 10.1111/j.1440-1819.1967.tb00079.x
Summary
The
responses of plasma HGH during psychiatric shock therapies were
investigated, and the mechanisms of HGH secretion and of shock therapies
were discussed.
1. The response following a sinall dose of i.v. insulin administrotion.
a)
The plasma HGH following 0.1 U/kg of i.v. insulin in schizophrenic
patients showed marked elevation in six out of seven cases. It reached
to the peak value of 30.4±9.2 mμg/ml between 60 and 90 minutes after
i.v. insulin.
b) This type of response was
not affected by the various psychotropic drugs that were administered
orally in controlling the mental symptoms of the patients.
c) Intramuscular injection of chlorpromazine (30–50 mg) did not alter the pattern of the plasma HGH response.
2. Insulin coma therapy
a)
A marked elevation of plasma HGH level was observed in all cases of
schizophrenia during insulin coma therapy. The peak value was 9–32
mμg/ml (average 22.6±8.1 mμg/ml).
b) A
tendency of delay in reaching the peak value was observed in the
determination performed in the second week of coma days as compared to
the initial determination in the early days of insulin coma. A tendency
was observed that better therapeutic results were correlated with the
absence of or decrease in the delay in reaching the peak value in the
course of insulin coma therapy.
c) The
protracted insulin coma was associated with the marked decrease in the
magnitude of the peak value of plasma HGH as compared to the initial
determination, suggesting the presence of a fatigued state of the
central mechanism regulating the secretion of HGH.
3. Electroshock therapy
a)
Elevation of the plasma HGH level was observed after electroshock
therapy in five of six cases of schizophrenia. A non-responsive case was
found to be moderately obese. A case of depression and a case of
atypical psychosis lacked HGH response after EST in the absence of
obesity.
b) The peak value after the
electroshock therapy was lower than the one during insulin coma therapy
or after administration of a small dose of i.v. insulin. The average
peak value after EST was 8.1±6.8 mμg/ml.
c)
The responsivity of plasma HGH was found to be unrelated to the various
prernedications, such as i.v. thiopental and succinylcholine chloride.
It was also concluded that the presence or absence of generalized
convulsion was not related to the responses of HGH following EST.
d) No correlation was found between the changes of blood sugar level and the type of plasma HGH responses following the EST.
It
was suggested that the elevation of HGH at the time of electroshock
therapy was induced by the direct electric stimulation of the
hypothalamic center, but the effect of stimulating the HGH secretion was
much lower than that induced by the insulin coma or i.v. insulin
administration.
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